07-25-2013, 05:06 PM
I don't see this as a mental issue at all and it does seem absurd that you know two people with the exact same problem. The mouse interface is a completely artificial and arbitrary one. In fact, apple recently completely reversed the scrolling interface (natural scrolling) so that vertical mouse movements work the opposite of the way they worked before. People adapt to the interface that's presented to them. Having the mouse go one way or the other to cause things to happen on the screen is arbitrary and something the human brain will adapt to. People may not like the change at first but after a while they forget about it.