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Yes, any capacity 3.5" SATA hard drive is going to work in your iMac G5.
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Be warned that it's not trivial replacing the HD in the white imacs. You really should check out the how-tos and watch the videos and factor a couple of hours and frayed nerves. Maybe not as bad as a white ibooks but a lot of stuff and cables that can be torn.
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Yes, the G5 iSight was the beginning of the end of easily replaced HDs.
The model before that was much easier to deal with, although upgrading RAM meant removing the back. Still, that's why I bought mine, and will need to replace the HD soon, as it's going to a friend.
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Thanks everyone. I will check out the "replace hard drive" videos on google.